| DATE | OPPONENT | SCORE | OVERALL/CONFERENCE |
| Aug 30 | Chattanooga | W 57-2 | 1-0 |
| Sep 6 | Cincinnati | W 52-26 | 2-0 |
| Sep 13 | at Washington | W 55-14 | 3-0 |
| Sep 27 | TCU | W 35-10 | 4-0 |
| Oct 4 | at Baylor* | W 49-17 | 5-0 / 1-0 |
| Oct 11 | Texas* | L 45-35 | 5-1 / 1-1 |
| Oct 18 | Kansas* | W 45-31 | 6-1 / 2-1 |
| Oct 25 | at Kansas State* | W 58-35 | 7-1 / 3-1 |
| Nov 1 | Nebraska* | W 62-28 | 8-1 / 4-1 |
| Nov 8 | at Texas A&M* | W 66-28 | 9-1 / 5-1 |
| Nov 22 | Texas Tech* | W 65-21 | 10-1 / 6-1 |
| Nov 29 | at Oklahoma State* | W 61-41 | 11-1 / 7-1 |
| Dec 6 | Missouri* Big 12 Conference Championship | W 62-21 | 12-1 / 8-1 |
| Jan 8 | Florida BCS Title Game | L 24-14 | 12-2 / 8-1 |