| DATE | OPPONENT | SCORE | OVERALL/CONFERENCE |
| Sep 1 | North Texas | W 79-10 | 1-0 |
| Sep 8 | Miami (FL) | W 51-13 | 2-0 |
| Sep 15 | Utah State | W 54-3 | 3-0 |
| Sep 21 | at Tulsa | W 62-21 | 4-0 |
| Sep 29 | at Colorado* | L 27-24 | 4-1 / 0-1 |
| Oct 6 | Texas* | W 28-21 | 5-1 / 1-1 |
| Oct 13 | Missouri* | W 41-31 | 6-1 / 2-1 |
| Oct 20 | at Iowa State* | W 17-7 | 7-1 / 3-1 |
| Nov 3 | Texas A&M* | W 42-14 | 8-1 / 4-1 |
| Nov 10 | Baylor* | W 52-21 | 9-1 / 5-1 |
| Nov 17 | at Texas Tech* | L 34-27 | 9-2 / 5-2 |
| Nov 24 | Oklahoma State* | W 49-17 | 10-2 / 6-2 |
| Dec 1 | Missouri* Big 12 Championship | W 38-17 | 11-2 / 7-2 |
| Jan 2 | West Virginia Fiesta Bowl | L 48-28 | 11-3 / 7-2 |